Mating, channels and kidney cysts

Article Abstract:

It has been possible to identify evidence that homologues of the polycystins act together in a signal-transduction pathway in sensory neurons. Another research project has shown that a homologue of polycystin-2 is connected with the activity of a cation channel. These findings support the view that polycystin-related proteins are part of a previously unknown class of signal-transduction molecules. The first project found that a mutation of the nematode worm Caenorhabditis elegans, which produces males that are defective in mating behaviour, lies in a gene named lov-1, the worm homologue of human polycystin-1.

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EPS8 and E3B1 transduce signals from Ras to Rac

Article Abstract:

Eps8, a substrate of receptors with tyrosine kinase activity which binds to a protein designated E3b1/Abi-1, participates with this protein in the transduction of signals from Ras to Rac. This occurs through the regulation of Rac-specific guanine nucleotide exchange factor activities. Positioning Eps8 in the mitogenic network made it possible to show that it is involved in the transduction of signals from Ras/PI(3)K to Rac. It is possible that Eps-8 like molecules represent a universal connection between small G proteins of the Rho-family.

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Grabbing phosphoproteins

Article Abstract:

Durocher and colleagues have reported a new twist on the way protein phosphorylation controls the assembly of complex cellular events such as DNA repair, actin rearrangement and programmed cell death. They show that a family of Forkhead-associated (FHA) domains can bind directly to phosphothreonine peptides.

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