More hippocampal neurons in adult mice living in an enriched environment

Article Abstract:

New research shows that mice living in an enriched environment have significantly increased numbers of neurons in the dentate gyrus of the hippocampus, compared with cohorts living in standard cages. The enriched environment also caused the mice to perform better in a water maze test. It cannot be proved that there is a cause-and-effect link between the enhanced behaviour and the increased neurons, but a contributing factor could be the combination of increased neurons, dendrites and synapses.

Author: Gage, Fred H., Kempermann, Gerd, Kuhn, H. Georg
Developmental neurology, Hippocampus (Brain), Cerebellar nuclei

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Wnt signalling regulates adult hippocampal neurogenesis

Article Abstract:

The adult hippcampal stem/progenitor cells (AHPs) express receptors and signalling components for Wnt proteins, which are key regulators of neural stem cell behaviour in embryonic development. The data shows that Wnt signalling is a principal regulator of adult hippocampal neurogenesis and provides evidence that Wnt proteins have a role in adult hippocampal function.

Author: Gage, Fred H., Consiglio, Antonella, Dieter-Chichung Lie, Colamarino, Sophia A., Hong-Jun Song, Desire, Laurent, Mira, Helena, Lein, Edward S., Jessberger, Sebastian, Lansford, Heather, Dearie, Alejandro R.
United States, Stem cells, Neurogenetics

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A role for adult TLX-positive neural stem cells in learning and behavior

Article Abstract:

Several researches and studies are conducted to explain the significance of the adult TLX-positive neural stem cells in the learning abilities and behavior of humans. The results prove that the newly generated neurons selectively contribute to the specific cognitive functions and hence are extremely essential.

Author: Evans, Ronald M., Gage, Fred H., Chun-Li Zhang, Yuhua Zou, Weimin He
Cell proliferation, Stem cell research, Cognitive neuroscience

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Subjects list: Research
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