Simulation and validation of modeled sphingolipid metabolism in Saccharomyces cerevisiae
Article Abstract:
A biochemical systems theoretical model of sphingolipid metabolism in yeast is validated experimentally. Simulations of metabolic fluxes, enzyme deletion and the effects of inositol has led to predictions that show significant concordance with experimental results generated post hoc.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Simulation methods, Simulation, Brewer's yeast, Saccharomyces cerevisiae, Sphingolipids
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Small molecule activators of SIRT1 as the therapeutics for the treatment of type 2 diabetes
Article Abstract:
The identification and characterization of small molecule activators of SIRT1, which could be used as a new therapeutic approach to treat diseases of ageing such as type 2 diabetes, is described.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Physiological aspects, Genetic aspects, Obesity, Type 2 diabetes, Glucose metabolism, Insulin
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Subjects list: Research
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