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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

P53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

Article Abstract:

A study was conducted to show that cardiac angiogenesis is crucially involved in the adaptive mechanism of cardiac hypertrophy and that p53 accumulation is essential for the transition from cardiac hypertrophy to heart failure. The result shows that p53 is a crucial regulator in the induction of maladaptive hypertrophy and that it does so by inhibiting cardiac angiogenesis.

Author: Asahara, Takayuki, Molkentin, Jeffrey D., Komuro, Issei, Harada, Mutsuo, Minamino, Tohru, Akazawa, Hiroshi, Sano, Masanori, Yunzeng Zou, Toko, Haruhiro, Miyauchi, Hideyuki, Orimo, Masayuki, Qin, Yingjie, Tateno, Kaoru, Kayama, Yosuke, Shimizu, Ippei, Hamada, Hirofumi, Tomita, Shuhei
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
DNA binding proteins, Heart enlargement, Heart hypertrophy

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The unusual suspect

Article Abstract:

The studies about p53 protein that indicate that it also plays significant role in regulating cytokine LIF expression in female fertility in addition to its function of tumour prevention is reviewed.

Author: Stewart, Colin L.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Cytokines, Fertility

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Subjects list: Research, Tumor suppressor genes, Tumour suppressor genes
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