RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
Article Abstract:
The receptor for advanced glycation end products (RAGE) is a potential cell-surface acceptor site for the neurotoxic amyloid-beta peptides in the brain of individuals with Alzheimer's disease. Higher levels of RAGE in brain cells with Alzheimer's disease indicates that it plays an important role in the pathogenesis of neurological dysfunction and death. Increased levels of amyloid-beta peptides, especially in Alzheimer's disease, leads to RAGE fixing onto cortical cells. This causes sustained cellular oxidant stress which adversely affects cellular function and organic homeostasis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
Article Abstract:
The neurotoxic peptide intracellular amyloid-beta (A-beta) has negative effects on cellular functions. In the case of Alzheimer's disease, trigger signal transduction may be prompted in the early stages by interactions with cell-surface receptors for A-beta. It is possible that the intracellular polypeptide known as ERAB normally functions in cellular metabolism and biosynthesis. A-beta may inhibit these functions. Further research is required into how ERAB affects the function of normal and perturbed cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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The problem of variation
Article Abstract:
Research is presented describing the fruitfly pigmentation and the importance of studying evolutionary and developmental biology jointly.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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