Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
Article Abstract:
Long-term potentiation (LTP) at hippocampal mossy fibre synapses is eliminated in mice without the synaptic vesicle protein Rab3A. It was not expected that short-term synaptic plasticity and forskolin-induced enhancement would be intact in the Rab3A-knockout mouse, as induction of mossy fibre LTP partly occludes paired-pulse facilitation, frequency facilitation and forskolin enhancement. This research presents the first connection between a protein of the secretory machinery at the synapse and a type of long-term synaptic plasticity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Is bigger better?
Article Abstract:
The synapse is a fundamental element of communication between neurons. Many molecular components involved in neurotransmitter exocytosis have been identified, but there have been difficulties defining postsynapitc molecular architecture. Researchers have reported a targeted mouse mutation, with a prominent PDZ-domain protein, post-synaptic density of 95. This confirms that PSD-95 is an important component of excitatory synapses, and indicates extended functions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Synaptic scaling mediated by glial TNF-alpha
Article Abstract:
Synaptical scaling in response to prolonged blockade of activity is mediated by the pro-inflammatory cytokine tumour-necrosis factor-alpha (TNF-alpha). It is also shown that glia are the source of the TNF-alpha that is required for this form of synaptic scaling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Opioids block long-term potentiation of inhibitory synapses. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
- Abstracts: The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus. Chaperone release and unfolding of substrates in type III secretion
- Abstracts: The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus. part 2 [AB.sub.5] subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP
- Abstracts: Experimental evidence for mutual inter-and intrasexual selection favouring a crested auklet ornament. Alliances II. Rates of encounter during resource utilization: A general model of intrasexual alliance formation in fission-fusion societies
- Abstracts: TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3