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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Structure of the E. coli signal recognition particle bound to a translating ribosome

Article Abstract:

Cryo-electron microscopy and single-particle reconstruction is used to obtain a 16 Angstrom structure of the Escherichia coli signal recognition particle (SRP) in complex with a translating E. coli ribosome containing a nascent chain with a transmembrane helix anchor. The structures have revealed the regions that are involved in complex formation, provided insights into the conformation of the SRP on the ribosome and have indicated the conformational changes that accompany high-affinity SRP binding to ribosome nascent chain complexes upon recognition of the signal sequence.

Author: Schaffitzel, Christiane, Ban, Nenad, Koerten, Henk K., Berger, Imre, Oswald, Miro, Ishikawa, Takashi, Abrahams, Jan Pieter, Koning, Roman I.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United Kingdom, Science & research, Research, Escherichia coli, Structure

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A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome

Article Abstract:

A three-dimensional model for the basic framework of protein synthesis is designed based on a 25-angstrom cryo-electron microscopic reconstruction of the ribosome from Escherichia coli. Four thousand three hundred projections of ice-embedded single particles were combined to reconstruct the ribosome. A channel in the small ribosomal subunit which may be a pathway for the incoming message and a bifurcating tunnel in the large subunit which might provide a pathway for the nascent polypeptide chain were discovered.

Author: Agrawal, Rajendra K., Frank, Joachim, Penczek, Pawel, Zhu, Jun, Li, Yanhong, Srivastava, Suman, Verschoor, Adriana, Radermacher, Michael, Grassucci, Robert, Lata, Ramani K.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Methods, Usage, Molecular structure, Electron microscopy, Protein research

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Subjects list: Ribosomes
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