Abstracts » Zoology and wildlife conservation

Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

Article Abstract:

The single-stranded-DNA-binding domain of human replication protein A (RPA) bound to DNA is composed of two structurally homologous subdomains. The single-stranded DNA (SSDNA) is found in a channel that runs across both subdomains. The structure of each RPA70 subdomain is similar to the structure of bacteriophage single-stranded-DNA-binding proteins. RPA70 is the largest subunit that binds to SSDNA and mediates interactions with cellular and viral proteins.

Proteins, DNA binding proteins, Protein structure

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Crystal structure of the CorA M[g.sup.2+] transporter

Article Abstract:

The CorA family of magnesium transporters is the primary M[g.sup.2+] uptake system of most prokaryotes and a functional homologue of the eukaryotic mitochondrial magnesium transporter. The crystal structures of the full-length Thermotoga maritima CorA in an apparent closed state and its isolated cytoplasmic domain at 3.9 Angstrom and 1.85 Angstrom resolution, respectively is determined.

Primary nonferrous metals, not elsewhere classified, Electric properties, Prokaryotes, Magnesium, Magnesium (Metal)

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Article Abstract:

The structures of human insulin-degrading enzyme (IDE) in complex with four substrates (insulin B chain, amyloid-beta peptide (1-40), amylin and glucagon) are reported. The molecular basis for substrate recognition and allosteric regulation of IDE might help in designing IDE-based therapies to control cerebral amyloid-beta and blood sugar concentrations.

Illinois, Protein synthesis, Protein biosynthesis, Crystallization, Structure, Allosteric enzymes

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