TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism

Article Abstract:

Crystallographic, mutational and functional analyses of complexes between Rab GTPases and the TBC (Tre-2, Bub2 and Cdc16) domain of Gyp1p, a GTPase-activating protein (GAP) are reported. The TBC domain of a TBC-domain-Rab-GTPase-aluminium fluoride complex, which approximates the transition-state intermediate for GTP hydrolysis, supplies two residues, an arginine and a glutamine finger, whose strong conservation indicates that most TBC-domain GAPs may accelerate GTP hydrolysis by a dual-finger mechanism.

Transition state (Chemistry), Guanosine triphosphatase, GTPases

---

Structural basis of family-wide Rab GtPase recognition by rabenosyn-5

Article Abstract:

The specificity and structural basis underlying the interaction of the multivalent effector rabenosyn-5 with the Rab family is determined. The results demonstrate that even the structurally similar effectors domains in rabenosyn-5 can achieve highly selective recognition of distinct subsets of Rab GTPases exclusively through interactions with the switch and interswitch regions.

Pharmaceutical Preparation Manufacturing, Biological products exc. diagnostic, Polyclonal Antibodies, Analysis, Gene mutations, Gene mutation, Crystallization, Properties, Structure

---

Legionella pneumophila proteins that regulate Rab1 membrane cycling

Article Abstract:

The functions of the Legionella pneumophila proteins that control the Rab1 activity are explained. The protein is found to regulate the Rab1 membrane cycling by redirecting it to the pathogen-occupied vacuole.

Physiological aspects, Genetic aspects, Biological transport, Phagocytes, Legionella pneumophila

Similar abstracts:

• Abstracts: Direct observation of the rotation of F(sub 1)-ATPase. Highly coupled ATP synthesis by F1-ATPase single molecules
• Abstracts: The elephant in the room. Recognition of Bacterial glycosphingolipids by natural killer T cells. Regulations of immunity by self-reactive T cells
• Abstracts: Assessment of Mars exploration rover landing site predictions. Aeolian processes at the Mars Exploration Rover Meridian Planum-landing site
• Abstracts: Hope in the hills for tundra? Parasite rattles diversity's cage. Where slugs may safely graze
• Abstracts: Doubling the estimate of invertebrate biomass in a rainforest canopy. FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.