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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Targeted gene knockdown experiments: Combining (super 18)O-Isotopic labeling and protein-AQUA(super TM)

Article Abstract:

(super 18)O enzymatic labeling and protein-AQUA is used in combination to provide a synergistic and efficient approach for the analysis of gene knockdown experiments. Protein-AQUA analysis enable absolute quantitation of the protein targeted for gene knockdown as the O enzymatic method is a global labeling procedure, and it allows for the elucidation of off-target effects, as well as the identification of related protein products affected by the knockdown event.

Author: Cockrill, Steven L., Porter, Jeffrey J., Ewing, Beth K., Mehigh, Richard J., Wildsmith, Justin, Kappel, William K., Scott, Graham B.I.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Protein research, RNA interference

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Written in blood

Article Abstract:

The potential use of carrier-protein-bound low-molecular-weight (LMW) blood biomarkers in blood proteomics is depicted. The combination of artificial intelligence, clinical proteomics and nanotechnology to monitor blood- biomarker archive will revolutionizing disease diagnosis carrier-protein-bound low-molecular-weight and health profile.

Author: Liotta, Lance A., Ferrari Mauro, Petricoin, Emanuel
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Biological markers

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An attractive force in metastasis

Article Abstract:

Issues are presented concerning the influence of metastasis in the failure of the treatment of patients suffering from cancer. The role played by soluble factors in attracting circulating cancer cells is discussed.

Author: Liotta, Lance A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Physiological aspects, Cancer, Metastasis, Cancer metastasis

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Subjects list: Research, Proteomics
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