Abstracts - faqs.org

Abstracts

Zoology and wildlife conservation

Search abstracts:
Abstracts » Zoology and wildlife conservation

The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas

Article Abstract:

The early expression of the Pax4 gene, a member of the murine family of Pax genes, in a subset of endocrine progenitors is necessary for the differentiation of the beta and delta cell lineages. The gene is expressed in the early pancreas, but is later limited to beta cells. In the absence of Pax4, the presence of glucagon cells in considerably higher numbers indicates that in Pax4(super -1-) pancreas, a substantial amount of early endocrine precursors have acquired an alpha-cell phenotype. However, it may be possible that the absence of beta and delta cells leads to an increased proliferation of alpha-cell precursors.

Author: Gruss, Peter, Oliver, Guillermo, Sosa-Pineda, Beatriz, Chowdhury, Kamal, Torres, Miguel
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Gene expression, Cell differentiation, Mammals, Pancreas

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas

Article Abstract:

It is possible to demonstrate that the paired-box gene Pax6 is expressed during the early stages of pancreatic development in mice, as well as in mature endocrine cells. There are no glucagon-producing cells in the pancreas of Pax6 homozygous mutant mice, indicating that Pax6 is vital to the differentiation of alpha-cells. It can be concluded that Pax4 and Pax6 determine the cell fate of endocrine tissue during development. It is believed that all four endocrine cell types are derived from a common pluripotent precursor which originates from the endoderm.

Author: Gruss, Peter, Mansouri, Ahmed, Sosa-Pineda, Beatriz, Chowdhury, Kamal, St-Onge, Luc
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Mice, Mice (Rodents), Animal anatomy, Pancreatic beta cells

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Ambra1 regulates autophagy and development of the nervous system

Article Abstract:

The study of autophagy processes in neurodegradation and cancer identified a new essential element supporting the complex interplay between autophagy, cell growth and death required for neural development in mammals.

Author: Gruss, Peter, Schwartz, Peter, Fimia, Gian Maria, Piacentini, Mauro, Stoykova, Anastassia, Romagnoli, Alessandra, Giunta, Luigi, Di Bartolomeo, Sabrina, Nardacci, Roberta, Corazzari, Marco, Fuoco, Claudia, Ucar, Ahmet, Chowdhury, Kamal, Cecconi, Francesco
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
United States, Science & research, Nervous system, Tumors, Embryonal, Embryonal tumors, Embryonal tumours, RNA interference, Embryonic stem cells

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Genetic aspects
Similar abstracts:
  • Abstracts: The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus. Chaperone release and unfolding of substrates in type III secretion
  • Abstracts: Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Synaptic scaling mediated by glial TNF-alpha
  • Abstracts: The cytohesin steppke is essential for insulin signalling in Drosophila. Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1
  • Abstracts: Two neurons mediate diet-restriction-induced longevity in C. elegans. When less is more
  • Abstracts: Bird-flu experts question advice on eating poultry. Iran refuses to cooperate with atomic agency. Academic freedom under threat in Iran
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2023 Advameg, Inc.