The nuclear hormone receptor Ftz-F1 is a cofactor of Drosophila homeodomain protein Ftz
Article Abstract:
The molecular factors and mechanisms that mediate the regulatory role of the fushi tarazu (ftz) gene during oogenesis were analyzed in Drosophila embryo nuclear extracts. Analysis of Drosophila embryo nuclear extracts indicated the role of the FTz-F1 gene in mediating the wild-type function f the ftz gene in Drosophila embryos during oogenesis. Furthermore, genetic analysis also indicated the presence of cooperative interactions between Ftz homeodomain protein and FTz-F1 gene which involved DNA binding.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Article Abstract:
A novel, quantitative, cellular assay monitoring extracellular-regulated kinases (ERK) activation is used to perform an unbiased, RNA interference (RNAi), genome-wide, high-throughput screen in Drosophila cells to understand the receptor tyrosine kinase (RTK)/ERK signalling. The ERK pathway output integrates a wide array of conserved cellular processes and novel regulators that modulate specific pathway output might be selective targets for drug discovery.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Functional genomics reveals genes involved in protein secretion and Golgi organization
Article Abstract:
A genome-wide RNA-mediated interference screen in a Drosophila cell line is performed to identify genes required for constitutive protein secretion. It is shown that depletion of class A genes redistributes Golgi membranes into the endoplasmic reticulum, depletion of class B genes leads to Golgi fragmentation, depletion of class C leads to aggregation of Golgi membranes, and depletion of class D genes causes no obvious change.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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