The power of clonal selection

Article Abstract:

A study conducted by Francisco Lozano et al. on the selection of cells expressing optimized antibodies in the immune system provide experimental support for the advantages offered by antibody-producing cells' single antibody specificity. They examined transgene copy expression in hybridomas obtained from immunized transgenic mice and found that somatic mutation occurred in most of the transgenes, making them distinguishable at the mRNA level. Their findings indicate that antibody-producing cells have several mechanisms for modulating antibody gene expression patterns and that the antibody response selects strongly for monospecific cells.

Immune response, Immune response regulation, Immunospecificity, Clonal selection theory, Clonal selection (Immunology)

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IgH class switching and translocations use a robust non-classical end-joining pathway

Article Abstract:

Studies are conducted to assess whether the classical non-homologous eng joining (C-NHEJ) is also vital for class-switch recombination (CSR) by assaying CSR in Xrcc4- or Lig4-deficinet mouse B cells. An alternative end-joining pathway has supported CSR in C-NHEJ-deficient B cells and it has frequently joined immunoglobulin (Igh) locus breaks to other chromosomes to generate translocations.

Science & research, Immunoglobulins, Bone marrow cells, Recombinant molecules

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Memory B-cell persistence is independent of persisting immunizing antigen

Article Abstract:

Research is presented concerning the immunological memory which is acquired by the immune system through the generation of T-cell-dependent responses. The maintenance of the antibody system is discussed.

Physiological aspects, Letter to the Editor, Antibodies, Antigen-antibody reactions

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