Thermodynamic beta-sheet propensities measured using a zinc-finger host peptide
Article Abstract:
The thermodynamic beta-sheet propensities of 20 common amino acids are measured using a zinc-finger host peptide. The amino acids were substituted into a guest site of the host system which were unfolded without bound metal. The propensities of each substance was determined using a competitive cobalt(II)-binding assay. The resulting scale indicated the thermodynamic origin of beta-sheet propensities.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Rings of destruction
Article Abstract:
It has been possible to design and test new antibiotics that selectively disrupt the cell membranes of target microorganisms. These antibiotics are based on a cyclic peptide structure, with the synthetic ring peptides having the advantage of being significantly smaller than the alpha-helical ones, thus boosting their ability to penetrate tissues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Ghrelin induces adiposity in rodents
Article Abstract:
The discovery of the peptide hormone gherlin is examined.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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