Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Article Abstract:
[E.sub.[mu]]-myc transgenic mice that are heterozygous for a Tip60 gene knockout allele are used for showing that Tip60 counteracts Myc-induced lymphomagenesis in a haplo-insufficient manner and in a time window that is restricted to a pre- or early-tumoral stage. It is shown that in both mouse and human, Tip60 has a haplo-insufficient tumour suppressor activity that is independent from its role within the ARF-p53 pathway.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
Article Abstract:
Hepatocyte growth factor (HGF) mediates a three-stage response, which results in the formation of branched tubular structures in epithelial cells. Tyrosine kinase, an HGF receptor, operates via a Src homology (SH2) docking site which activates signalling pathways. It is show that the third phase depends on the STAT pathway, with HGF stimulating recruitment of Stat-3 to the receptor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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The MET oncogene drives a genetic programme linking cancer to haemostasis
Article Abstract:
A mouse model of sporadic tumorigenesis based on genetic manipulation of somatic cells is developed. An activated, human MET oncogene is targeted to adult liver and it was found to cause slowly progressing hepatocarcinogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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