Toll-dependent selection of microbial antigens for presentation by dendritic cells

Article Abstract:

Dendritic cells constitutively sample the tissue microenvironment and phagocytose both microbial and host apoptotic cells, which leads to the induction of immunity against invading pathogens or tolerance to peripheral self-antigens, respectively. The outcome of antigen presentation by dendritic cells depends on their activation status, such as Toll-like receptor (TLR)-induced dendritic cell activation, which makes them immunogenic, whereas steady-state presentation of self-antigens leads to tolerance.

Antigens, Dendritic cells

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Gene-specific control of inflammation by TLR-induced chromatin modifications

Article Abstract:

The article identifies two classes of toll-like receptor induced genes which regulates inflammation when infection takes place in the body.

Causes of, Inflammation, Chromatin, Cell receptors, Genetic research

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Recognition of microorganisms and activation of the immune response

Article Abstract:

A general overview of the mammalian immune system and its function in host defence against microorganisms is presented.

Virulence (Microbiology), Immune response, Immune system, Host-parasite relationships

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