HIV reverse transcription in yeast
Article Abstract:
The reverse transcription indicator gene his3AI was mixed with hybrid Ty/HIV elements to prove that HIV-1 RT/RH can replace the reverse transcriptase/ribonuclease H (RT/RH) of the Ty1 retrotransposon in Saccharomyces cerevisiae. Hybrid Ty/HIV-1 elements or HARTs were observed to give the first accurate living cells analyses for RNA-dependent polymerase and RNase H interactions of HIV-1 RT/RH outside the virus. A basic genetic assay in S. cerevisiae was recommended to be feasible for testing drugs that prevent the RT/RH of HIV-1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Epigenetic inheritance in plants
Article Abstract:
The role of RNA in epigenetic inheritance in plants and its use in controlling development are studied. Plants have used the epigenetic silencing mechanisms for controlling the development and parent-of-origin imprinted gene expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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