Functional association of Nmi with Stat5 and Stat1 in IL-2 and IFNgamma-mediated signaling

Article Abstract:

A study was conducted to analyze the association of Nmi, a protein reported as an N-Myc interactor. The function of Nmi in Interleukin-2-responsive YT cells was also examined. Experimental results indicated that the protein can potentiate transcription and augment coactivator protein recruitment to members of a group of sequence-specific transcription factors. Findings also showed that Nmi lacks an intrinsic inactivation domain.

Analysis, Cells (Biology), Proteins, Cells

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Nonfilamentous C. albicans mutants are avirulent

Article Abstract:

Candida albicans, a fungal pathogen, can change from a yeast to a filamentous form. Two regulatory proteins Ste12p and Phd1p regulate the change in Saccharomyces. Single-mutant strains are partly defective, whereas the double mutant is entirely defective and noninvasive in filamentous growth. In a mouse model, the Candida cph1/chh1 efg1/efg1 double mutant in the yeast form, was found to be avirulent.

Saccharomyces, Candida albicans

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