A Drosophila I(kappa)B kinase complex required for Relish cleavage and antibacterial immunity

Article Abstract:

A Drosophila I(kappa)B kinase complex containing DmIKK(beta) and DMIKK(gamma) has been identified. The complex is necessary for Relish cleavage and antibacterial immunity. A yet-to-be-identified I(kappa)B kinase complex is apparently required for Rel protein activation via the Toll signaling pathway.

Sweden, Cellular signal transduction

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The antibacterial arm of the Drosophila innate immune response requires an I(kappa)B kinase

Article Abstract:

The Drosophila innate immune response is discussed. It must have an I(kappa)B kinase for antibacterial activity. The ird5 gene has a sequence and phenotype that suggest ird5 to be specifically necessary for the activation of Relish, a Drosophila NF-(kappa)B family member.

Peptides, Bacterial infections

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NF-kappaB signaling pathways in mammalian and insect innate immunity

Article Abstract:

NF-kappaB signaling pathways in mammalian and Drosophila innate immunity are discussed in this review article. Both similarities and differences are seen in comparisons. Similar pathogen-derived substances activate the innate immune response in both.

Genetic aspects, Cellular control mechanisms, Cell regulation, Mammals

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