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A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q

Article Abstract:

The spleen and C3 provides resistance against blood-borne S. pneumoniae infection, to understand the mechanisms involved SIGN-RI is studied, a lectin that captures microbial polysaccharides in spleen. It is found that SIGN-R1 directly bound the complement C1 subcomponent, C1q, and assembled a C3 convertase, but without the traditional requirement for either antibody or factor B.

Author: Steinman, Ralph M., Lynch, Rebecca M., Young-Sun Kang, Yoonkyung Do, Hae-Kyung Lee, Sung Ho Park, Cheolho Cheong, Loeffler, Jutta M., Chae Gyu Park
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
United States, All Other Basic Organic Chemical Manufacturing, Industrial organic chemicals, not elsewhere classified, Polysaccharides, Ligands (Biochemistry), Pneumonia, Pneumococcal, Pneumococcal pneumonia

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Article Abstract:

An approach is described to pharmacologically interrogate the PI3-K family. It is found that p110alpha is the primary insulin-responsive PI3-K in cultured cells, whereas p110beta is dispensable but sets a phenotypic threshold for p110alpha activity.

Author: Knight, Zachery A.; Gonzalez, Beatriz, Feldman, Morri E.; Zunder, Eli R., Goldenberg, David D.; Williams, Olusegun, Loewith, Robbie; Stokoe, David; Balla, Andras; Toth, Balazs, Balla, Toth; Weiss, William A.; Williams, Roger L.; Shokat, Kevan M.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Phenotype, Phenotypes, Insulin, Pharmacology

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