A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

Article Abstract:

Histone deacetylase Rpd3 and its functional interaction with the corepressor Groucho are discussed relative to Drosophila development. The Drosophila gene groucho, gro, (ital) encodes a transcriptional corepressor with critical roles in many development processes. Now Gro has been used as an affinity reagent to purify Gro-binding proteins from embryonic nuclear extracts and one of the proteins was found to be Rpd3. It appears that Gro and Rpd3 form a complex in vivo and interact directly via the glycine-proline rich (GP) domain in Gro. Mutations in gro (ital) and rpd3 (ital) have synergistic effects on embryonic lethality and pattern formation.

Statistical Data Included, Developmental biology, Embryology, Experimental, Embryological research, Drosophila

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Transcriptional repression: the long and the short of it

Article Abstract:

Research reveals that regulation of gene expression is mediated by transcriptional repressors through long-range and short-range repression. Data suggest that both long- and short-range repression may recruit histone deacetylases to mediate repression by an interaction between gene repressors and gene activators.

Enzymes, Gene expression, Genetic transcription, Transcription (Genetics), Enzyme regulation

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Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras reponse

Article Abstract:

Yan polymerization and the Yan/Mae interaction regulate the interaction between Yan and Crm1. The stringency of the Ras response is increased with the antagonistic regulation of Yan nuclear export by Mae and Crm1.

Science & research, Genetic research, Ras genes

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