Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

Article Abstract:

Analysis of p53-regulated (tumor suppressor gene-regulated) gene expression patterns has been carried out using oligonucleotide arrays. The oligonucleotide microarrays were used to measure mRNA levels from a large number of genes regulated by the p53 transcription factor. It was found that the nature to the p53 response in different mRNA species depends on the cell type, levels of p53 protein in a cell, and the type of inducing agent or event.

Usage, Measurement, Nucleic acid probes, Genetic regulation, Cytochemistry, Tumor suppressor genes, Messenger RNA, DNA binding proteins

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CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals

Article Abstract:

Research has been conducted on mammalian p53 protein. The authors report that this protein can activate apoptosis via the pathway similar to that of Drosophila and involves HTRA2 gene and subsequent inhibition of mammalian homolog of Drosophila inhibitor of apoptosis by cleavage.

Physiological aspects, Proteases, Drosophila, Serine, Genetic research, Chemical inhibitors, Apoptosis

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a

Article Abstract:

This article discusses the study of the p53 tumor suppressor protein that can activate gene transcription and repress the expression of specific genes. Data presented show the importance of this activity for apoptosis induction by this protein.

Cell death, Proteins, Molecular biology, Molecular genetics

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