R-spondin1-discovery of the long-missing, mammalian female-determining gene?

Article Abstract:

The sex determination process in mammals, for long described as a male determination process, is challenged by the discovery that the gene encoding R-spondin1 is mutated in human patients with female-to-male sex reversal. The possible roles of R-spondin1 during sex determination are discussed.

United States, Sexual behavior, Analysis, Gene mutations, Gene mutation, Sex determination, Genetic, Sex determination (Genetics), Y chromosome

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Mammalian histidine decarboxylase: From structure to function

Article Abstract:

A comprehensive review of the structural and functional characteristics of mammalian histidine decarboxylase is presented. Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity.

Histidine, Decarboxylases

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