Homeodomain-mediated [beta]-catenin-dependent switching events dictate cell-lineage determination

Article Abstract:

An unexpected strategy for [beta]-catenin-dependent regulation of cell-lineage determination based on interactions between [beta]-catenin and a specific homeodomain factor, Prop1, is presented. A novel transcriptional strategy that underlies [beta]-catenin control of cell-lineage determination in organogenesis is discovered during the study.

Genetic regulation, Catenanes

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CAMTA in cardiac hypertrophy

Article Abstract:

Calmodulin binding transcription activator 2 (CAMTA2) is an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the disassociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5

Hypertrophy, Calmodulin

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