The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages

Article Abstract:

The mechanism of hematopoietic lineages in multipotent stem cells was studied by analyzing the development of eosinophils and basophils from purified granulocyte/monocyte progenitors (GMPs). It was found that although either cell type requires both GATA-2 and C/EBP[alpha] for their development, the order of expression of these transcription factors is critical to selectively activate the program for each of these lineages by which stem cell could generate multiple lineage cells in a hierarchical manner.

Hematopoiesis, Genetic research

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Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression

Article Abstract:

Transcription termination factor Pcf11 and its effect on the processivity of RNA polymerase II (Pol II) and HIV provirus was studied. It was shown that the termination factor Pcf11 causes premature termination on an HIV provirus and Pcf11 can act as a negative elongation factor to repress RNA Pol II gene expression in eukaryotic cells.

Eukaryotes, RNA polymerases

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The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons

Article Abstract:

The manner in which K1f7 binds to the endogenous TrkA minimal enhancer and activate transcription from the TrkA minimal enhancer in the sequence dependent manner is shown. Thus, K1f7 regulates TrkA gene expression and is required for the development of a subset of nonciceptive sensory neurons.

Sensory receptors, Zinc finger proteins

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