A molecular target for viral killer toxin: TOK1 potassium channels

Article Abstract:

A molecular plasma membrane target for K1 toxin, known to bring uncontrolled leading of potassium, protons, ATP and other small molecules from target cells in Saccharomyces cerevisiae, has been found. Killer strains of S. cerevisiae have doublestrand RNA viruses and ccrete protein toxins that kill virus-free cells. TOK1 is an outwardly rectifying, potassium-selective ion channel. The toxin activates this plasma membrane potassium channel. Channels have also been studied in Xenopus laevis oocytes.

Statistical Data Included, Viruses, Potassium channels, Xenopus, Microbial toxins

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Saccharomyces telomeres acquire single-strand TG(1-3) tails late in S phase

Article Abstract:

Telomere replication in Saccharomyces is a process which involves the formation of TG(1-3) tails at the DNA termini as replication intermediates. Nondenaturing Southern hybridization showed that this intermediate is formed late in S phase. Two-dimensional gel electrophoresis also detected linear plasmids possessing TG(1-3) tails which were able to mediate stable telomere-telomere interactions.

Telomeres, Cell cycle

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The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in robosomal DNA

Article Abstract:

It has been shown that the Saccharomyces Pif1p DNA helicase and the strongly related Rrm3p affect replication fork progression in robosomal DNA in opposite ways. The Pif1p helicase and the related Rrm3p were rDNA associated in vivo. Loss of Rrm3p increased rDNA breakage and accumulation of rDNA circles. In pif1 cells, breakage and circles were less common.

Carrier proteins, Transport proteins, Enzymes, Recombinant DNA, Genetic recombination, Chromosome replication

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