A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease

Article Abstract:

Research was conducted to identify a multilocus sequence typing scheme (MLTS) and database for Streptococcus pneumoniae that could be used to determine the major clones related to serious invasive pneumococcal disease. The relationship between serotypes and sequence types indicates that capsular genes have been distributed horizontally within the pneumococcal population but the expansion of clones occurs with only occasional changes of serotype. The MLTS provides a powerful approach to the study of global molecular epidemiology of pneumococcal diseases.

Research, Clone cells

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Unconventional organization of the division and cell wall gene cluster of Streptococcus pneumoniae

Article Abstract:

Research was conducted to examine the sequence and organization of the genes responsible for cell wall biosynthesis and cell division (dcw genes) in Streptococcus pneumoniae. Results indicated that the organization of the dcw genes is different in many respects from that of the clusters of other Gram-negative and Gram-positive bacteria. Despite the variations observed among the isolates, the genetic organization of the dcw clusters of G54 is representative of S pneumoniae.

Microbiological synthesis, Bacterial cell walls, Cell division

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Genetic relationships among Pasteurella trehalosi isolates based on multilocus enzyme electrophoresis

Article Abstract:

Multilocus enzyme electrophoresis analysis was successful in establishing genetic similarities and differences within sixty strains of British Pasteurella trehalosi pathogens. Isolates with four capsular serotypes T3, T4, T10 and T15 were selected, many of which are responsible for causing systemic pasteurellosis in sheep. The method proved helpful in population genetics research and could also be used in epidemiology.

Methods, Electrophoresis, Population genetics, Bovine pneumonic pasteurellosis

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