A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells
Article Abstract:
A novel form of the AP-1 clathrin adaptor complex is discussed. It mediates basolateral targeting in polarized epithelial cells and contains as a subunit micro1B, an epithelial cell-specific homolog of the widely expressed micro1A. Basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex having micro1B in it.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptor
Article Abstract:
Research shows that the familial hypercholesterolemia receptor mutant is mistargeted to the apical surface of Madin-Darby canine kidney and hepatic epithelial cells, leading to a reduction in LDL endocytosis. Data suggest that expression of a defective polarized LDL receptor in hepatocytes leads to hypercholesterolemia.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Dendritic cells: specialized and regulated antigen processing machines
Article Abstract:
The purpose of this minireview is to discuss the publication on the dendritic cells. The ability of these cells to capture and process antigens in a distinct manner has been investigated and the results are presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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