Mutants of Mycobacterium smegmatis impaired in stationary-phase survival

Article Abstract:

Researchers describe seven mutants of Mycobacterium smegmatis that had defects in stationary-phase survival. Homologous genes were found in the Mycobacterium tuberculosis genome that code for a penicillin-binding protein and a polyketide synthase.

Mycobacteria, Mycobacterium

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A purF mutant of Mycobacterium smegmatis has impaired survival during oxygen-starved stationary phase

Article Abstract:

A Mycobacterium smegmatis purF mutant has been found to have limited survival in the oxygen-starved stationary phase. A range of transposon mutants of M smegmatis was shown to be not greatly affected in oxygen-starved stationary-phase survival. Implications for M. tuberculosis exist because the M. smegmatis purF gene encodes a protein much like the PurF homologues of M tuberculosis and M. leprae. The gene was cloned and shown to substantially complement the oxygen-starvation phenotype.

Statistical Data Included, Gene mutations, Gene mutation, Oxygen, Bacteria, Mycobacterium tuberculosis, Cytochemistry, Transposons, Purines, Carrier state (Communicable diseases)

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Regulation of expression of the cyanide-insensitive terminal oxidase in Pseudomonas aeruginosa

Article Abstract:

Research has been conducted on cyanide-insensitive oxidation regulation in Pseudomonas aeruginosa. The authors suggest that O (sub)2 fails to affect cyanide-insensitive oxidase expression in P. aeruginosa due to the loss of the exponential-phase-specific repressing signal.

Science & research, Analysis, Oxidases, Microbiology, Genetic regulation, Gene expression, Pseudomonas aeruginosa, Cyanides

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