A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation

Article Abstract:

Trypanosoma brucei, an African trypanosome that causes sleeping sickness, and its antigenic variation have been studied and a role for RAD51 and homologous recombination found. The variation is useful as an evasion strategy for dealing with immunity, from time to time switching expression of variant surface glycoprotein (VSG) genes. For switching it can change the transcriptional status between an active and an inactive copy of the site of VSG expression or recombination reactions.

United Kingdom, Genetic recombination, Parasites, Medical parasitology, Parasitology, Trypanosomatidae, Trypanosomatina

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The yeast exosome and human PM-Sc1 are related complexes of 3' --> 5' exonucleases

Article Abstract:

Human PM-Sc1 and the yeast exosome are discussed with information that they are related complexes of 3' --> 5' exonucleases, based on biochemical and genetic analyses that have found six novel components of the complex. The complex has 11 components, 10 of which are predicted to be 3' --> 5' exoribonucleaes, based on sequence homology. Strong indication that the PM-Scl complex is directly homologous to the yeast exosome has been found.

Denmark, Scleroderma (Disease), Polymyositis, Ribonuclease

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Distinct protein interaction domains and protein spreading in a complex centromere

Article Abstract:

Protein spreading in a complex centromere and distinct protein interaction domains are discussed. Fission yeast, Schizosaccharomyces pombe, centromeres are more evocative of higher eukaryotic centromeres than those of budding yeast. They are made up of large inverted repeats with heterochromatic features and are a good model, therefore, for higher eukaryotic centromeres.

Physiological aspects, Chromatin

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