A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint

Article Abstract:

The ability of an internal telomeric sequence to inhibit a DNA damage checkpoint response is described. DSB (double-strand breaks) adjacent to a telomeric repeat sequence successfully activated the DNA damage checkpoint response, which was lost 1-2h later so it is proposed that after formation of the DSB near the telomeric repeat, a mature telomere forms, containing proteins that inhibit checkpoint signaling from nearby DNA breaks.

Telomeres, DNA damage

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Eukaryotes learn how to count: Quorum sensing by yeast

Article Abstract:

The universal strategies that characterize bacterial quorum sensing are reviewed and a glimpse is provided of the diverse physiological settings in which it operates. A discussion is presented on evidence for quorum sensing in different fungal species, considering an especially compelling case in the budding yeast Saccharomyces cerevisiae.

Eukaryotes, Quorum sensing

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