Multilineage transcriptional priming and determination of alternate hematopoietic cell fates

Article Abstract:

A cellular system was established to analyze mixed lineage transcriptional priming and its resolution in the context of macrophage versus neutrophil cell fate determination. The model revealed general features of transcriptional networks that might regulate cell fate decisions in diverse cellular patterning events, including those associated with embryonic development.

Science & research, Research, Genetic transcription, Transcription (Genetics), Cellular control mechanisms, Cell regulation, Hematopoiesis

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Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease

Article Abstract:

The authors have investigated cyclobutane thymine dimer, a DNA lesion which is a primary cause of skin cancer. They report that six-factor human excision nuclease recognizes and removes the dimer, and present the recognition mechanism allowing the low-specificity recognition factors to locate the lesion and form a high-specificity complex at the damage site.

Biological Product (except Diagnostic) Manufacturing, Natural Gas Liquid Extraction, Drugs, Natural gas liquids, Thymine, Normal Butane, Analysis, Causes of, Physiological aspects, Genetic aspects, DNA repair, Skin cancer, Genetic research, Cyclic compounds, Butane, Nucleases

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