Abberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polygmutamine disease are rescued by CREB-binding protein

Article Abstract:

Research has been conducted on transcriptional coactivator CREB-binding protein which is involved in the pathogenesis of polygmutamine expansion neurodegenerative disease. The authors describe the use of Drosophila model in demonstrating that polygmutamine-induced neurodegeneration is caused by a defect in histone acetylation and transcription profile alteration.

United States, Analysis, Causes of, Physiological aspects, Histones, Retinal degeneration, Glutamine, Binding proteins

---

High resolution ChIP-chip analysis reveals that Drosophila MSL complex selectivity identifies active genes on the male X chromosome

Article Abstract:

X-chromosome-specific male specific lethal (MSL) binding is defined at high resolution in two male cell lines and in late-stage embryos. Results support a model in which the MSL complex selectively identifies target genes in the context of active transcription.

Science & research, Research, X chromosome

---

Similar abstracts:

• Abstracts: The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation
• Abstracts: Conditions of formation, purification, and characterization of an alpha-galactosidase of Trichoderma reesei RUT C-30
• Abstracts: Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway
• Abstracts: Bioaccumulation of the herbicide diclofop in extracellular polymers and its utilization by a biofilm community during starvation
• Abstracts: Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Facilitation of dendritic mRNA transport by CPEB

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.