An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Article Abstract:

Steroid hormones penetrate cells by diffusion through the plasma membrane. However, it was observed that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. It was also discovered that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorved in the proximal tubules by the endocytic receptor megalin.

Physiological aspects, Kidneys, Kidney, Steroid hormones, Vitamin D3

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Response: Cellular uptake of sex steroid hormones

Article Abstract:

The role of megalin, an endocytic receptor of the low-density lipoprotein (LDL) receptor gene family, in reproductive tissues is discussed. Impaired development of male and female reproductive tissues and sex steroid insensitivity is a result of deficiency in the megalin receptor.

Denmark, Science & research, Low density lipoproteins, Hormones, Sex, Sex hormones, Structure

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