Role of endocytosis in cellular uptake of sex steroids

Article Abstract:

The possible role of megalin in the cellular delivery of sex steroids and the consequences of receptor deficiency for androgen and estrogen action in vivo are investigated. The findings uncover the existence of endocytic pathways for protein bound androgens and estrogens and their critical role in development of the reproductive organs.

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"Bound" to work: The free hormone hypothesis revisited

Article Abstract:

Megalin is a member of the low-density lipoprotein receptor-related protein (LRP) family. A demonstration reveals that resistance to sex steroid hormones is encountered in animals lacking megalin, thus providing insight into an endocytic mechanism for the uptake of sex steroids by mammalian cells.

Low density lipoproteins

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Sex steroids and the free hormone hypothesis

Article Abstract:

The role of endocytic receptor megalin and sex hormone binding globulin (SHBG) on the cellular uptake of sex steroid hormones in mice is discussed. Megalin is found to be crucial for the internalization of sex steroids bound to SHBG.

New York, Physiological aspects, Rats, Rattus

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