An expectation-maximization algorithm for the analysis of allelic expression imbalance

Article Abstract:

An expectation-maximization algorithm for analysis of allelic expression imbalance (AEI) providing a formal statistical framework is presented to test whether a candidate polymorphism is associated with allelic expression differences. It is observed that the cis-acting polymorphisms are important in determining interindividual differences in gene expression that lead to allelic expression imbalance.

Genetic polymorphisms, Genetic variation

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Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis

Article Abstract:

A systematic analysis of global gene-expression patterns helped in finding that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis. A genetic association was found between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients.

United States, Health aspects, Genetic aspects, Atopic dermatitis

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The genetics of congenital amusia (tone deafness): a family-aggregation study

Article Abstract:

An argument whether congenital amusia can be genetically transmitted is studied. It is concluded that congenital amusia is expressed by a deficit in processing musical pitch but not musical time and also show that the pitch disorder has a hereditary component.

Genetic disorders

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