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Ancestral Asian source(s) of New World Y-chromosome founder haplotypes

Article Abstract:

It appears that more than one paternal migration from the general region of Lake Baikal to the Americas took place. Haplotypes made from Y-chromosome markers have been used to trace origins of Native Americans, relating them to an ancestral Asian source or sources. A sample of 2,198 males from 60 global populations, 19 of them Native American and 15 of them indigenous to North Asia has been tested. From 12 biallelic polymorphisms, 14 unique Y-chromosome haplotypes arose and were distributed unevenly in the populations. Results show the possibility of two or more Native American paternal founder haplotypes.

Author: Templeton, A.R., Karafet, T.M., Zegura, S.L., Posukh, O., Osipova, L., Bergen, A., Long J., Goldman, D., Klitz, W., Harihara, S., Knijff, P. de, Wiebe, V., Griffiths, R.C., Hammer, M. F.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
Asia, Central America, North America, South America, Genetic aspects, Emigration and immigration, Native Americans, Human beings, Native North Americans, Humans, Asians, Emmigration and immgration, America

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Familial disclosure in defiance of nonconsent

Article Abstract:

The statement concerning 'Professional Disclosure of Familial Genetic Information' by the American Society of Human Genetics (ASHG) is misguided. The ASHG statement supports the breaching of patient confidentiality to disclose information on genetic risks to family members when treatment or avoidance of serious risk of harm is possible. However, consent to familial involvement should be discussed with the patient before testing. The provider can decide whether or not to perform the test if the patient is unwilling to authorize familial disclosure.

Author: Merz, Jon F., Sankar, Pamela, Cho, Mildred K., Knoppers, Bartha Maria
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
Social aspects, Social policy, Ethical aspects, Informed consent (Medical law), Informed consent, Medical genetics, American Society of Human Genetics

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A gene for familial juvenile polyposis maps to chromosome 18q21.1

Article Abstract:

A gene for familial juvenile polyposis (FJP) has been mapped to chromosome 18q21.1, based on a genomic screen of a large five-generation family from the Midwestern US. The pedigree includes 29 members with FJP and/or gastrointestinal cancer. Genotyping was carried out for 13 affected individuals, 24 considered at risk and six spouses. The gene appears to be located in an 11.9-cM interval between D18S1118 and D18S487, where the tumor-suppressor genes DCC and DPC4 are situated.

Author: Summers, Robert W., Howe, James R., Stone, Edwin M., Ringold, John C., Mitros, Frank A., Nishimura, D.Y.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
Research, Polyposis, Familial, Familial polyposis

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