Associative overdominance, heterozygosity and fitness

Article Abstract:

Researchers investigated the power of associative overdominance in creating a correlation between individual heterozygosity and fitness and in maintaining genetic polymorphism at neutral loci. This was done by simulating a diploid model with five chromosomes. Various combinations such as population size, number of crossovers, selection coefficient, and dominance were used. All combination of parameter values resulted in positive regression, even though fitness differences were not large. The link between individual heterozygosity and fitness was clear for recessive mutations. The results showed that associative overdominance could help maintain polymorphisms in small populations.

Heterozygosis, Heterozygote

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Are polymorphism and evolutionary rate of allozyme proteins limited by mutation or selection?

Article Abstract:

A computer simulation suggests that mutation rather than selection is more likely to control the polymorphism and evolutionary rate of allozyme proteins. The range of models that can account for the variation in allozyme heterozygosity and genetic distance through type or intensity of selection is fairly narrow, whereas mutation rate can more easily explain the variation through a wider range of models.

Natural selection, Mutation (Biology), Mutation, Isoenzymes

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