BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of trancriptional activators of the mammalian clock system

Article Abstract:

Research has been conducted on mammalian CLOCK and BMAL1 proteins. The authors have investigated the abundance, circular localization and posttranslational modifications of endogenous and ectopically expressed CLOCK and BMAL1 proteins, and they report that the regulation of transcriptional activity and availability of CLOCK/BMAL1 complex is responsible for the additional level of circadian system control.

Proteins, Circadian rhythms, Gene expression, Genetic transcription, Transcription (Genetics), Phosphorylation

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TSC2 mediates cellular energy response to control cell growth and survival

Article Abstract:

Research shows that the tumor suppressor gene TSC2 regulates the common mTOR pathway, involved in protein synthesis, cell growth, and viability in response to cellular energy status. Results show that under energy-deprived conditions, TSC2 is phosphorylated, enhancing its activity, to facilitate translation regulation and cell size control during tuberous sclerosis complex (TSC).

Analysis, Cells (Biology), Growth, Energy metabolism, Genetic regulation, Bioenergetics, Cells, Tumor suppressor genes, Company growth, Sclerosis, Tumour suppressor genes

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