Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci

Article Abstract:

Messenger RNA transcription and expression of the mouse alpha- and beta-globin loci in development have been characterized. All seven murine globin genes are transcribed in primitive erythropoiesis, but transcription of three of them is restricted to the primitive erythroid lineage. There is evidence of EKLF activity in embryonic red cells. It may be that there is multigene expression in the beta locus takes place though alternating single-gene transcription although coinitiation may be part of the alpha locus. It seems that the multigene expression mechanism of alternation transcription is evolutionarily conserved from mouse to human beta globin loci. Timing of activation of the adult genes is not the same, however, so important fundamental differences likely exist in globin gene switching.

Netherlands, Genetic aspects, Mice, Mice (Rodents), Genetic regulation, Gene expression, Messenger RNA, Heredity

---

The active spatial organization of the beta-globin locus requires the transcription factor EKLF

Article Abstract:

Three-dimensional organization of a gene locus is important for its regulation, as recently demonstrated for the beta-globin locus. It is reported that erythroid Kruppel-like transcription factor (EKLF), an erythroid transcription factor required for adult beta-globin gene transcription is also required for active chromatin Hub (ACH).

Science & research, Chromatin

---

Similar abstracts:

• Abstracts: Shaping morphogen gradients. bantam Encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
• Abstracts: Effects of chlorobenzoate transformation on the Pseudomonas testosteroni biphenyl and chlorobiphenyl degradation pathway
• Abstracts: Regulation of maternal messenger RNA translation during oogenesis and embryogenesis in Urechis caupo. XLPOU-60, a Xenopus POU-domain mRNA, is oocyte-specific from very early stages of oogenesis, and localised to presumptive mesoderm and ectoderm in blastula
• Abstracts: Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Soluble dimeric prion protein binds PrP(sup)Sc in vivo and antagonizes prion disease
• Abstracts: Cell cycle regulated transport controlled by alterations in the nuclear pore complex. A new role for Ran in ensuring precise duplication of chromosomal DNA

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.