Balancing import and export in development

Article Abstract:

Characterization of the homeoprotein-containing regulatory complexes, when it comes, will be helpful to elucidation of molecular mechanisms that underlie the control of morphological diversity by Hox genes in animal development. Effects of hexapeptide mutations in vivo on targets that are well defined will make the investigation of the HOX proteins possible in the absence of cooperativity. Mutations in homeodomains that get rid of DNA binding may give some insight into composition of the complex on in vivo targets.

Genetic aspects, Intestines, Developmental biology, Genetic regulation, Genetic transcription, Transcription (Genetics), Genetic disorders, Neural tube

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An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo

Article Abstract:

The Drosophila gene 'punt' encodes a homolog of a vertebrate type II receptor and is essential in vivo for decapentaplegic (dpp)-dependent patterning processes along with type I and type II receptors. The Drosophila thick veins (tkv) gene product is a type I receptor for dpp. The lack of dpp-related signaling in the absence of either the punt or tkv receptor shows that both receptors act together to transduce the dpp signal and that their functions cannot be substituted by the other type I and II receptors.

Drosophila

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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells

Article Abstract:

Results describe structural homology of the novel transmembrane protein 'Dispatched' with sequence similarity to Drosophila and vertebrate Patched receptor. The data indicate Dispatched is required to release cholestrol-anchored Hedgehog family of secreted proteins into cells.

Physiological aspects, Proteins, Cell receptors, Hedgehogs, Cholesterol metabolism

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