Biocatalytic conversion of avermectin to 4'-oxo-avermectin: Improvement of cytochrome P450 monooxygenase specificity by directed evolution

Article Abstract:

The development of a cytochrome P450 oxidases (CYP) enzyme with highly improved substrate regiospecificity that can be employed for the biocatalytic conversion of avermectin to 4'-oxo-avermectin is discussed. Enzyme variants with significantly improved specificity for the production of 4'-oxo-avermectin were identified as process consisting of four successive rounds of GeneReassembly evolution.

Enzymes for Food Processing, Cytochrome P-450, Genetic variation

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Lactic acid bacteria as a potential source of enzymes for use in vinification

Article Abstract:

Studies done on the potential of LAB as a source of enzymes that could improve wine quality and complexity are presented. The results of the study demonstrate that these organisms possess an extensive collection of enzymatic activities, many of which have the potential to influence wine composition and therefore the processing, organoleptic properties, and quality of wine.

Industrial Organic Chemicals, Lactic Acid, Microbiological research

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