Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

Article Abstract:

Functional and genomic analyses have shown required coordination between the unfolded protein response (UPR) and endoplasmic reticulum (ER)-associated degradation. The transcriptional scope of the UPR has been determined through use of DNA microarrays. The UPR affects multiple ER and secretory pathway functions.

Research, Endoplasmic reticulum, Cytochemistry

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Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response

Article Abstract:

The unfolded protein response pathway in endoplasmic reticulum is controlled by Hac1p transcription factor that is produced when intron at the 3'end of mRNA is removed. Data show that a base-pairing interaction between the intron and 5' region of mRNA blocks mRNA translation.

Statistical Data Included, Genetic regulation, Genetic transcription, Transcription (Genetics), Messenger RNA

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A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

Article Abstract:

Results demonstrate that induction of unfolded protein response in mammalian cells involves proteolytic cleavage of transmembrane kinase/endoribonuclease Ire1 and that presenilin-1 controls Ire1 proteolysis.

Nuclear membranes, Nuclear membrane, Proteolysis

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