CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint

Article Abstract:

Cells in the process of meiotic development must have C1b-dependent cyclin-dependent protein kinase (CDK) activity for replication of DNA. In the budding yeast the B-type cyclins C1b5 and C1b6 are the main activators of the S phase function of CDK Cdc28. Diploid c1b5/c1b5 clb6/c1b6 mutants cannot carry out premeiotic DNA replication. A DNA replication checkpoint that depends on the ATM homolog MEC1 operates in wild-type cells in meiosis. It can be invoked as a response to inhibition of DNA synthesis. CLB5 and CLB6 are necessary for premeiotic DNA replication and activation of the meiotic S/M checkpoint.

Genetic aspects, DNA, Yeast, Yeast (Food product), Meiosis

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The DNA-dependent protein kinase

Article Abstract:

The DNA-dependent protein kinase (DNA-PK), the physiological targets of which are still not precisely identified, is activated when associated with DNA and DNA damage. DNA-PK is critical in DNA DSB repair. DNA-PK parts have roles in other ways, among them controlling telomeric integrity and chromatin structure. Identification of novel double-strand break (DSB) repair components working with DNA-PK will be important. More will be found out about functionally regulated kinases and how they deal with genomic damage as more is found out about DNA-PK.

United Kingdom, Gene mutations, Gene mutation, DNA repair, DNA damage, Genetic transcription, Transcription (Genetics), Genetic disorders

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