Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

Article Abstract:

MEC1 and RAD53 are essential genes for the cell cycle and transcriptional responses to DNA damage and DNA replication blocks. Essential function of these genes has been studied. Mec1 is more important than Rad53 in response to inhibition of DNA synthesis, based on study of viable null alleles. Their lethality defects can be suppressed by greater expression of genes encoding ribonucleotide reductase. However, that is not the case for the checkpoint defects. It appears that the checkpoint pathway plays has an important role in maintaining DNA synthetic capabilities when DNA replication is stressed.

Observations, Chromosome replication, Nucleotides, Meiosis

---

Control of ribonucleotide reductase localization through an anchoring mechanism involving WTM1

Article Abstract:

The control of deoxyribonucleotide levels is essential for DNA synthesis and repair that is exerted through regulation of ribonucleotide reductase (RNR) is reported. It suggests that WTM1 acts as a nuclear anchor to maintain nuclear localization of Rnr2/4 complexes outside of S phase and in the presence of DNA damage this association is disrupted and Rnr2/Rnr4 become cytoplasmic, where they join with Rnr1 to form an intact complex.

Cytoplasm, DNA synthesis

---

Adaptor protein Ste50p links Ste11p MEKK to the HOG pathway through plasma membrane association

Article Abstract:

The regulatory role of Ste50p requires both the N-terminal Sterile alpha motif domain to bind the mitrogen extracellular signal-regulated kinase kinase (MEKK) Ste11p and the C-terminal Ras association-like domain to direct kinase localization. An integral membrane protein, Opy2p can interact with Ste50p, as a component in the Sho1p-Ste11p/Ste50p signaling branch of the high-osmolarity glycerol (HOG) pathway.

All Other Basic Organic Chemical Manufacturing, CHEMICALS AND ALLIED PRODUCTS, Glycerine, Membrane proteins, Cell membranes, Glycerol, Chemical properties, Glycerin

Similar abstracts:

• Abstracts: DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Visualization of replication factories attached to a nucleoskeleton
• Abstracts: Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway. Optimization of procedures for counting viruses by flow cytometry
• Abstracts: Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the Drosophila trachea. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
• Abstracts: Hox and wings. The choroid plexus in the rise, fall and repair of the brain
• Abstracts: Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K(super +) channel

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.