Cadherins in development: Cell adhesion, sorting, and tissue morphogenesis

Article Abstract:

The distributions and functions of different cadherins in the formation and maintenance of tissues and the mechanisms in regulating cadherin activity are examined. The cadherin family not only plays important roles based on their primary function in the formation of cell-cell adhesions, but has also evolved to specify cell-cell recognition and sorting, boundary formation in tissues, coordination of multicell movements and the establishment and maintenance of cell and tissue polarity.

Genetic regulation, Cell adhesion

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Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

Article Abstract:

A critical involvement of sema6D in cardiac morphogenesis that exerts region-specific activities on cardiac explants and a migration-inhibitory activity on those from the ventricle is demonstrated. Plexin-A1 forms a receptor complex with vascular endothelial growth factor receptor type 2 in the conotruncal segment or with Off-track in the ventricle segment.

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Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development

Article Abstract:

Signaling pathways that govern embryonic coronary development is explored to identify novel therapeutic targets. It is demonstrated that Hedgehog (HH) is necessary for coronary vascular development and activation of HH signaling is sufficient to promote coronary growth and to rescue coronary defects due to loss of fibroblast growth factor (FGF) signaling.

Genetic aspects, Cellular signal transduction, Fibroblast growth factors, Hedgehogs, Structure

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