Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite

Article Abstract:

Calcium and a calcium-dependent protein kinase (CDPK4) are shown to be essential for the sexual reproduction and mosquito transmission of P.berghei. An unexpected function for a plant-like signaling pathway in cell cycle regulation and life cycle progression of a malaria parasite is revealed.

Pharmaceutical Preparation Manufacturing, All Other Basic Inorganic Chemical Manufacturing, Pharmaceutical preparations, Industrial inorganic chemicals, not elsewhere classified, Calcium, Calcium Supplements, Calcium (Nutrient), Malaria, Calcium, Dietary, Parasitic diseases, Sexual reproduction

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Higher-order substrate recognition of elF2alpha by the RNA-dependent protein kinase PKR

Article Abstract:

X-ray crystal structures of the catalytic domain of PKR in complex with elF2alpha are determined. The structures reveal that elF2alpha binds to the C-terminal while the N-terminal lobe mediates catalytic-domain dimerization.

RNA

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The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks

Article Abstract:

A study on CK2, the essential protein kinase is presented. The result shows that this protein maintains genetic integrity of mammalian cells by repairing breaks in chromosomal strands.

Genetic aspects, Mammals, Chromosomes, Genetic research

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