The molecules of mammalian fertilization

Article Abstract:

The proteins required for mammalian fertilization are present in the egg zona pellucida (ZP) and sperm plasma membrane. The ZP3 protein is responsible for species-specific binding in mouse. The O-linked oligosaccharides on ZP3 are responsible for sperm binding and signaling needed for acrosome reaction. The beta-1,4 galactosyl transferase, a 56 kDa protein and the p95 tyrosine-phosphorylated protein function as ZP3 adhesion molecules on acrosome-intact mouse sperms. Integrins are also involved in sperm-egg binding.

Research, Physiological aspects, Proteins, Molecular biology, Cell adhesion, Spermatozoa, Sperm, Fertilization (Biology), Zona pellucida

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The mouse Fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Article Abstract:

The mechanisms that mediate axis formation in mammalian embryos were analyzed in mice to characterize the role of the fish Fused locus which encodes the axin inhibitor. Analysis of the fish Fu locus indicated the presence of a novel inhibitor of Wnt signaling pathway that regulated an early the early stages of embryonic axis formation in fish. Furthermore, the expression of the axin protein inhibited dorsal axis formation via the Wnt signaling pathway.

Genetic aspects, Fishes, Developmental biology, Cell differentiation, Embryology, Animal embryology

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