Chiasma interference as a function of genetic distance

Article Abstract:

A model showing the relation of meiotic double crossing over interference with genetic distance was developed. The model showed that recombinational intermediates are distributed at random with interference resulting from constraints on their resolution. The basic constraint would be having intermediates that cross over (Cx) in between a pair of intermediates that do not cross over (Co). The number of intervening Cos is estimated from the fraction of gene conversions unaccompanied by crossover of flanking markers. The model was tested on Drosophila and Neurospora crassa chromosomes.

Models, Genetic aspects, Genetic recombination, Drosophila, Neurospora, Crossing over (Genetics)

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The amber mutants of phage T4

Article Abstract:

The discovery of amber mutants of phage T4 was one part of the early research incorporating genetic methods to analyze development. The first developments in this area occurred in 1966 through phage radiobiology and the adoption of the multiplicity reactivation theory to explain why irradiated T2 produced viable progeny phage. Radiobiology was then performed on T4 with a semi-molecular model of multiplicity reactivation developing. The later discovery of amber mutants and their ts cousins led to phage science moving beyond contemporary genetic and radiobiological theories.

Research, History, Bacteriophages, Radiobiology

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Alexander Hollaender: myth and mensch

Article Abstract:

Radiation biologist Alexander Hollaender was a genius. Although relatively unknown to the younger generation of scientists at Oak Ridge National Laboratory (ORNL), Hollaender rediscovered the 'oxygen effect' and was the first to note the resemblance between the absorption spectrum of nucleic acids and the action spectrum for spore mutation of the ring-worm fungus Trichophyton mentagrophytes.

Appreciation, Biologists, Hollaender, Alexander

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