Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Article Abstract:

It has been shown that p53 and ARF potentiate Myc-induced apoptosis in primary pre-B-cell cultures. Spontaneous inactivation of the ARF-Mdm2-p53 pathway is frequent in tumors in E-mu-myc transgenic mice. Myc activation selects strongly for spontaneous inactivation of the ARF-Mdm2-p53 pathway in vivo. It cancels the protective checkpoint function and speeds progress to malignancy.

Statistical Data Included, Research, Usage, Cell death, B cells, Cellular control mechanisms, Cell regulation, Immunocytochemistry, Lymphomas, Tumor suppressor genes, Carcinogenesis, Genetically modified mice

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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

Article Abstract:

The authors analyzes the study on cell survival regulation. The topics of interest include the role of serine/threonine kinase Pim-2 in growth factor-mediated apoptotic resistance in hematopoeitic cells.

Research and Development in the Physical, Engineering, and Life Sciences, Cellular Biology, Analysis, Physiological aspects, Growth factors, Genetic regulation, Protein kinases, Cytology, Hematopoiesis, Cytokines, Serine, Genetic research, Threonine, Apoptosis

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